abstract：:Several studies have implicated a potential role for histamine H(3) receptors in pain processing, although the data are somewhat conflicting. In the present study we investigated the effects of the novel potent and highly selective H(3) receptor antagonists GSK189254 (6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepi...

journal_title：Pain

authors： Medhurst SJ,Collins SD,Billinton A,Bingham S,Dalziel RG,Brass A,Roberts JC,Medhurst AD,Chessell IP

更新日期：2008-08-15 00:00:00

abstract：:In the present study the question was addressed whether sensitivity to experimental pain stimuli differs between families, which are previously characterized by the degree of cold tolerance (very insensitive or very sensitive) of one family member. A total of 232 healthy medical students were screened for cold pain to...

journal_title：Pain

authors： Birklein F,Depmeier C,Rolke R,Hansen C,Rautenstrauss B,Prawitt D,Magerl W

更新日期：2008-08-15 00:00:00

abstract：:Altered pain sensitivity is believed to play an important role for chronification of headache. It has however mainly been evaluated in highly selected patients from headache clinics and never in longitudinal studies. The present study is a 12-year follow-up of a population-based study of primary headache disorders and...

journal_title：Pain

authors： Buchgreitz L,Lyngberg AC,Bendtsen L,Jensen R

更新日期：2008-07-31 00:00:00

abstract：:When faced with the problem of pain one can attempt a solution aimed at relief (assimilation) or a solution aimed at acceptance (accommodation). Using this dual process model of adaptation to pain, this study compares acute and chronic pain patients on their approach to problem solving. Three hundred and sixty-four pa...

journal_title：Pain

authors： Crombez G,Eccleston C,Van Hamme G,De Vlieger P

更新日期：2008-07-31 00:00:00

abstract：:In previous studies we demonstrated that protein kinase D1 (PKD1/PKCmu) could directly phosphorylate the transient receptor potential V1 (TRPV1) at its N-terminal region and enhance the function of TRPV1 in CHO cells stably transfected with TRPV1. In the current study we assessed the involvement of PKD1 in pain modula...

journal_title：Pain

authors： Zhu H,Yang Y,Zhang H,Han Y,Li Y,Zhang Y,Yin D,He Q,Zhao Z,Blumberg PM,Han J,Wang Y

更新日期：2008-07-31 00:00:00

abstract：:Idiopathic chronic pain conditions with a mismatch between anatomical abnormalities and symptoms can be categorized as somatoform pain disorder according to the DSM-IV criteria. A dysfunction of pain processing circuits has been suggested as one underlying pathophysiological factor. There is accumulating evidence for ...

journal_title：Pain

authors： Gündel H,Valet M,Sorg C,Huber D,Zimmer C,Sprenger T,Tölle TR

更新日期：2008-07-15 00:00:00

abstract：:We studied whether striatal alpha(2)-adrenoceptors or N-methyl-d-aspartate (NMDA) receptors influence descending regulation of neuropathic hypersensitivity in the rat by microinjecting an alpha(2)-adrenoceptor agonist or NMDA-receptor antagonist into the dorsal striatum in animals with a spinal nerve ligation-induced ...

journal_title：Pain

authors： Pertovaara A,Wei H

更新日期：2008-07-01 00:00:00

abstract：:Cross-sectional research in clinical samples, as well as experimental studies in healthy adults, suggests that the experiences of pain and sleep are bi-directionally connected. However, whether sleep and pain experiences are prospectively linked to one another on a day-to-day basis in the general population has not pr...

journal_title：Pain

authors： Edwards RR,Almeida DM,Klick B,Haythornthwaite JA,Smith MT

更新日期：2008-07-01 00:00:00

abstract：:This was a multicenter, double-blind (DB), placebo-controlled, randomized discontinuation trial to evaluate the efficacy of pregabalin monotherapy for durability of effect on fibromyalgia (FM) pain. The trial included a 6-week open-label (OL) pregabalin-treatment period followed by 26-week DB treatment with placebo or...

journal_title：Pain

authors： Crofford LJ,Mease PJ,Simpson SL,Young JP Jr,Martin SA,Haig GM,Sharma U

更新日期：2008-06-01 00:00:00

abstract：:Pain is generally considered to have a sensory and an affective component. Clinical research has suggested that morphine more potently attenuates the affective component as compared to the sensory component. Because preclinical nociception models typically focus on the sensory component of nociception, and do not asse...

journal_title：Pain

authors： van der Kam EL,De Vry J,Schiene K,Tzschentke TM

更新日期：2008-06-01 00:00:00

abstract：:Acute microinjection of mu-, delta-, or kappa-opioid receptor (MOPr, DOPr, KOPr) agonists into the rostral ventromedial medulla (RVM) produces antinociception. Thermal antinociception produced by MOPr and DOPr agonists is potentiated during inflammation [Hurley RW, Hammond DL. The analgesic effects of supraspinal mu a...

journal_title：Pain

authors： Schepers RJ,Mahoney JL,Shippenberg TS

更新日期：2008-06-01 00:00:00

abstract：:Since a number of patients with Parkinson's Disease (PD) complain of painful sensations, we studied whether the central processing of nociceptive inputs is abnormal in PD. To test this hypothesis, we recorded scalp CO(2) laser evoked potentials (LEPs) to hand skin stimulation in 18 pain-free PD patients with unilatera...

journal_title：Pain

authors： Tinazzi M,Del Vesco C,Defazio G,Fincati E,Smania N,Moretto G,Fiaschi A,Le Pera D,Valeriani M

更新日期：2008-05-01 00:00:00

abstract：:Hindlimb pain models developed in rats have been transposed to mice, but assumed sciatic nerve neuroanatomic similarities have not been examined. We compared sciatic nerve structural organization in mouse strains (C57BL/6J, DBA/2J, and B6129PF2/J) and rat strains (Wistar, Brown Norway, and Sprague-Dawley). Dissection ...

journal_title：Pain

authors： Rigaud M,Gemes G,Barabas ME,Chernoff DI,Abram SE,Stucky CL,Hogan QH

更新日期：2008-05-01 00:00:00

abstract：:Recent studies demonstrate that some brain structures activated by pain are also engaged when an individual observes someone else in pain, and that these empathy-related responses are modulated as a function of the affective link between the empath and the individual in pain. In this study we test the hypothesis that ...

journal_title：Pain

authors： Loggia ML,Mogil JS,Bushnell MC

更新日期：2008-05-01 00:00:00

abstract：:The purpose of this study was to assess if the functional activation caused by painful stimuli could be detected with arterial spin labeling (ASL), which is a non-invasive magnetic resonance imaging (MRI) technique for measuring cerebral blood flow (CBF). Because ASL directly measures blood flow, it is well suited to ...

journal_title：Pain

authors： Owen DG,Bureau Y,Thomas AW,Prato FS,St Lawrence KS

更新日期：2008-05-01 00:00:00

abstract：:The roles of central protein kinases A and C (PKA and PKC) in various pain states have intensively been investigated during the past decade. The aim of the present study was to investigate the peripheral involvement of PKA and PKC in persistent nociceptive response, evoked pain behaviors, and inflammation induced by s...

journal_title：Pain

authors： Chen HS,Lei J,He X,Qu F,Wang Y,Wen WW,You HJ,Arendt-Nielsen L

更新日期：2008-03-01 00:00:00

abstract：:Increased blood pressure and sweet taste are often associated with decreased pain sensitivity. Animal research suggests that endogenous opioids are involved in both these relationships. Fifty-eight healthy young adults (36 male, 22 female) participated in two sessions receiving a placebo tablet or 50mg of naltrexone o...

journal_title：Pain

authors： Lewkowski MD,Young SN,Ghosh S,Ditto B

更新日期：2008-03-01 00:00:00

abstract：:Facial expressions of pain and emotions provide powerful social signals, which impart information about a person's state. Unfortunately, research on pain and emotion expression has been conducted largely in parallel with few bridges allowing for direct comparison of the expressive displays and their impact on observer...

journal_title：Pain

authors： Simon D,Craig KD,Gosselin F,Belin P,Rainville P

更新日期：2008-03-01 00:00:00

abstract：:The effects of nitrous oxide (N2O) are thought to be mediated by several pharmacological pathways at different levels of the central nervous system. Here, we focus on excitatory glutamatergic transmission in the superficial dorsal horn of the spinal cord with respect to its importance for the nociceptive processing. T...

journal_title：Pain

authors： Georgiev SK,Kohno T,Ikoma M,Yamakura T,Baba H

更新日期：2008-01-01 00:00:00

abstract：:We have constructed and validated the Elderly Pain Caring Assessment 2 (EPCA-2) an 8 items behavioural scale to rate the intensity of pain in non-verbally communicating older (age 65 years) patients (NVC-OP). It was postulated that the assessed pain had two dimensions (signs outside and during caregiving). The first v...

journal_title：Pain

authors： Morello R,Jean A,Alix M,Sellin-Peres D,Fermanian J

更新日期：2007-12-15 00:00:00

abstract：:The proinflammatory cytokine interferon-gamma (IFN-gamma), which can be present in elevated levels in the central nervous system during pathological conditions, may be involved in the generation of persistent pain states by inducing neuronal hyperexcitability. The aim of the present study was to examine whether loss o...

journal_title：Pain

authors： Vikman KS,Duggan AW,Siddall PJ

更新日期：2007-12-15 00:00:00

abstract：:The influence of contextual factors on the pain evoked by a noxious stimulus is not well defined. In this study, a -20 degrees C rod was placed on one hand for 500 ms while we manipulated the evaluative context (or 'meaning') of, warning about, and visual attention to, the stimulus. For meaning, a red (hot, more tissu...

journal_title：Pain

authors： Moseley GL,Arntz A

更新日期：2007-12-15 00:00:00

abstract：:Intra-articular injection of Freund's complete adjuvant (FCA) into the rat knee joint produces a swelling of the joint and long lasting hypersensitivity. In this study we have used this model and in vivo electrophysiology to investigate the time course of spinal changes underlying chronic secondary hypersensitivity, b...

journal_title：Pain

authors： Martindale JC,Wilson AW,Reeve AJ,Chessell IP,Headley PM

更新日期：2007-12-15 00:00:00

abstract：:Patients with neuropathic pain (NP) are challenging to manage and evidence-based clinical recommendations for pharmacologic management are needed. Systematic literature reviews, randomized clinical trials, and existing guidelines were evaluated at a consensus meeting. Medications were considered for recommendation if ...

journal_title：Pain

authors： Dworkin RH,O'Connor AB,Backonja M,Farrar JT,Finnerup NB,Jensen TS,Kalso EA,Loeser JD,Miaskowski C,Nurmikko TJ,Portenoy RK,Rice ASC,Stacey BR,Treede RD,Turk DC,Wallace MS

更新日期：2007-12-05 00:00:00

abstract：:Chronic pain is gender-related, since there is a clear predominance of one sex with respect to the other in most pain syndromes. Gonadal hormones are known to affect the occurrence and incidence of pain. Transsexuals receive cross-sex hormones to develop and maintain somatic characteristics of the opposite sex: male t...

journal_title：Pain

authors： Aloisi AM,Bachiocco V,Costantino A,Stefani R,Ceccarelli I,Bertaccini A,Meriggiola MC

更新日期：2007-11-01 00:00:00

abstract：:The objective of this preliminary study was to examine the extent to which affective marital interaction related to depressive symptoms in persons with chronic pain and their spouses and to pain severity in persons with pain. Couples from the community completed self-report surveys and engaged in a videotaped conversa...

journal_title：Pain

authors： Johansen AB,Cano A

更新日期：2007-11-01 00:00:00

abstract：:Metastatic bone cancer causes severe pain that is primarily treated with opioids. A model of bone cancer pain in which the progression of cancer pain and bone destruction is tightly controlled was used to evaluate the effects of sustained morphine treatment. In cancer-treated mice, morphine enhanced, rather than dimin...

journal_title：Pain

authors： King T,Vardanyan A,Majuta L,Melemedjian O,Nagle R,Cress AE,Vanderah TW,Lai J,Porreca F

更新日期：2007-11-01 00:00:00

abstract：:Poor women and women of color are disproportionately affected by HIV and this is particularly evident in sub-Saharan Africa. Even with increased access to antiretroviral therapy that makes HIV/AIDS a chronic manageable condition, little progress has been made to address the issues of pain caused by HIV disease in wome...

journal_title：Pain

authors： Gray G,Berger P

更新日期：2007-11-01 00:00:00

abstract：:Central pain following traumatic brain injury (TBI) has not been studied in depth. Our purpose was to conduct a systematic study of patients with TBI suffering from chronic central pain, and to describe the characteristics of the central pain. Groups were TBI patients with (TBIP) and without central pain (TBINP) and h...

journal_title：Pain

authors： Ofek H,Defrin R

更新日期：2007-10-01 00:00:00

abstract：:Recent studies indicate that reactive oxygen species (ROS) play an important role in neuropathic pain, predominantly through spinal mechanisms. Since the data suggest that ROS are involved in central sensitization, the present study examines the levels of activated N-methyl-d-aspartate (NMDA) receptors in the dorsal h...

journal_title：Pain

authors： Gao X,Kim HK,Mo Chung J,Chung K

更新日期：2007-10-01 00:00:00

abstract：:Trigeminal neuralgia (TN) is a rare form of neuropathic facial pain characterised by severe, paroxysmal pains in the face. Little is known about the decision process in treatment of TN, and management with anti-epileptic drugs or surgical procedures carries risks of side effects, recurrence and complications. One hund...

journal_title：Pain

authors： Spatz AL,Zakrzewska JM,Kay EJ

更新日期：2007-10-01 00:00:00

abstract：:Aquaporin 1 (AQP1) is the archetypal member of a family of water channel proteins that contribute to water homeostasis in kidney, lung, and other tissues. Although there is limited evidence that aquaporins are expressed in the nervous system, AQP4 is expressed in glia and AQP9 is present on some neuronal and glial mit...

journal_title：Pain

authors： Shields SD,Mazario J,Skinner K,Basbaum AI

更新日期：2007-09-01 00:00:00

abstract：:The purpose of this study was to explore gender differences in pain experiences, pain control beliefs, pain coping strategies, and depressive tendency among Chinese elderly with knee osteoarthritis (OA). Participants (N=199) were drawn from a previous convenience sample of outpatients with OA in Taiwan. Results indica...

journal_title：Pain

authors： Tsai YF

更新日期：2007-07-01 00:00:00

abstract：:Pain is a complex human trait. It is likely that the interaction of multiple genes, each with a small individual effect, along with the effect of environmental factors, influences the clinical efficacy of opioids rather than a single gene alone. Polymorphisms in genes coding for the mu-opioid receptor (A118G) and cate...

journal_title：Pain

authors： Reyes-Gibby CC,Shete S,Rakvåg T,Bhat SV,Skorpen F,Bruera E,Kaasa S,Klepstad P

更新日期：2007-07-01 00:00:00

abstract：:Nociceptive impulse activity was recorded extracellularly from single A delta and C primary afferents of the guinea pig's medial articular nerve after induction of an experimental osteoarthritis in the knee joint by partial medial menisectomy and transection of the anterior cruciate ligament (PMM+TACL). Also, the anal...

journal_title：Pain

authors： Gomis A,Miralles A,Schmidt RF,Belmonte C

更新日期：2007-07-01 00:00:00

abstract：:Changes in pain produced by psychological factors (e.g., placebo analgesia) are thought to result from the activity of specific cortical regions. However, subcortical nuclei, including the periaqueductal gray and the rostroventral medulla, also show selective activation when subjects expect pain relief. These brainste...

journal_title：Pain

authors： Goffaux P,Redmond WJ,Rainville P,Marchand S

更新日期：2007-07-01 00:00:00

abstract：:There are few prospective studies assessing risk factors for onset of temporomandibular (TMD) pain disorders in any age group. The aim of this prospective cohort study was to identify risk factors for onset of clinically significant TMD pain (i.e., pain meeting research diagnostic criteria for myofascial pain and/or a...

journal_title：Pain

authors： LeResche L,Mancl LA,Drangsholt MT,Huang G,Von Korff M

更新日期：2007-06-01 00:00:00

abstract：:Pain that interferes with daily life appears to be strongly age-related in cross-sectional studies, although the nature of this relationship over time has not been established. We have investigated the onset and persistence of pain and pain interference over a 3-year period to determine their association with age in o...

journal_title：Pain

authors： Thomas E,Mottram S,Peat G,Wilkie R,Croft P

更新日期：2007-05-01 00:00:00

abstract：:Atypical odontalgia (AO) is an intraoral pain condition of currently unknown mechanisms. In 10 AO patients and 10 matched healthy controls, we examined the effect of intravenous infusion of an N-methyl-D-aspartate (NMDA) receptor antagonist S-ketamine and a mu-opioid agonist fentanyl on spontaneous AO pain and on an a...

journal_title：Pain

authors： Baad-Hansen L,Juhl GI,Jensen TS,Brandsborg B,Svensson P

更新日期：2007-05-01 00:00:00

abstract：:Neuropathic pain behaviour is not observed in neonatal rats and tactile allodynia does not develop in the spared nerve injury (SNI) model until rats are 4 weeks of age at the time of surgery. Since activated spinal microglia are known to play a key role in neuropathic pain, we have investigated whether the microglial ...

journal_title：Pain

authors： Moss A,Beggs S,Vega-Avelaira D,Costigan M,Hathway GJ,Salter MW,Fitzgerald M

更新日期：2007-04-01 00:00:00